diff -ur a/py-smbus/Module.mk b/py-smbus/Module.mk
--- a/py-smbus/Module.mk	2014-02-20 09:37:15.711233000 +0100
+++ b/py-smbus/Module.mk	2019-12-14 08:20:51.730946457 +0100
@@ -22,7 +22,7 @@
 	rm -rf py-smbus/build
 
 install-python:
-	$(DISTUTILS) install
+	$(DISTUTILS) install --prefix=$(DESTDIR)$(PREFIX)
 
 all: all-python
 
